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Caloric restriction and spatial learning in old mice

L L Bellush1, A M Wright, J P Walker

  • 1Department of Psychology, Ohio University, Athens 45701, USA.

Physiology & Behavior
|August 1, 1996
PubMed
Summary
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Aging impairs spatial learning in mice, with calorie restriction offering no protection. Some older mice, however, showed learning abilities comparable to younger mice, suggesting potential for identifying mechanisms of cognitive decline.

Area of Science:

  • Neuroscience
  • Aging Research
  • Cognitive Science

Background:

  • Aging is associated with cognitive decline, particularly in spatial learning.
  • Caloric restriction is a potential intervention to mitigate age-related deficits.

Purpose of the Study:

  • To compare spatial learning abilities between aged and young mice.
  • To investigate the effect of caloric restriction on age-related spatial learning deficits.
  • To identify potential mechanisms underlying cognitive aging.

Main Methods:

  • Two experiments using the Morris water maze to assess spatial learning in aged (19-24 months) and young mice.
  • One group of aged mice underwent caloric restriction starting at 14 weeks of age.
  • Probe trials were used to evaluate memory retention and search strategies.

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Main Results:

  • Aged mice demonstrated significant deficits in spatial learning compared to young mice, regardless of diet.
  • Caloric restriction did not prevent or ameliorate age-related spatial learning impairments.
  • A subset of aged mice exhibited spatial learning performance indistinguishable from young controls.

Conclusions:

  • Aging significantly impairs spatial learning in mice.
  • Caloric restriction is ineffective in protecting against these age-related cognitive deficits.
  • Identifying the factors contributing to unimpaired spatial learning in some aged mice may reveal targets for combating cognitive decline.