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Synthesis of deuterated 7-(5'-deoxy-5'-methylthio-beta-D-ribofuranosyl)adenine-d3
1Department of Agricultural Chemistry, Meiji University, Kanagawa, Japan.
Nucleic Acids Symposium Series
|January 1, 1995
Abstract:
Synthesis of 7-(5'-deoxy-5'-methyl-thio-beta-D-ribofuranosyl)-adenine(7-MTA) has been developed from imidazole through 7-beta -D-ribofuranosyladenine. Deuterated 7-MTA-d3 was also synthesized by this synthetic procedure using deuterium labelled dimethyl disulfide-d6. The deuterium content of 7-MTA-d3 was 98.28%. The spectral and chemical properties of 7-MTA were defined.