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A facile synthesis of 4'-thio-arabinonucleosides as potential antiviral agents from D-glucose
Y Yoshimura1, M Watanabe, S Sakata
1Research and Development Division, Yamasa Corporation, Chiba, Japan.
Nucleic Acids Symposium Series
|January 1, 1995
Abstract:
As potential antiviral agents, 4'-thio-arabinonucleosides were synthesized. Methyl 3-O-benzyl-xylo-furanoside, readily obtained from D-glucose, was converted to 1,4-anhydro-4-deoxy-4-thio-arabinitol. The protection of hydroxyl groups and the Pummerer rearrangement, followed by Lewis acid induced glycosylation afforded 4'-thio-arabinonucleosides. The compounds showed anti HSV-1 activity.