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Preparation of pentofuranoside derivatives having ethynylene group and their reactions with oligodeoxyribonucleotides
K Sakagami1, H Yamaga, A Ogawa
1Department of Chemisty, College of Science and Engineering, Aoyama Gakuin University, Tokyo, Japan.
Nucleic Acids Symposium Series
|January 1, 1995
Abstract:
Furanoside derivatives having ethynylene group and related compounds were prepared. The reaction of these functionalized furanosides with oligodeoxy-ribonucleotide (21 mer, 5'-32P-GATAAGCTTGAAT TCATGGCC-3') and subsequent treatment with piperidine resulted in cleavage of the oligonucleotide.