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Updated: Jul 28, 2026

Quantitative Analysis of Dietary Vitamin A Metabolites in Murine Ocular and Non-Ocular Tissues Using High-Performance Liquid Chromatography
Published on: December 27, 2024
Safety aspects of vitamin A administration
1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA.
Objective:
To review longstanding experience in the safe use of vitamin A as therapeutic agent in prematurely born human neonates and more recently with young children infected with the respiratory syncytial virus (RSV).
Design:
The studies reviewed were designed to intervene with vitamin A in the form of retinyl palmitate in human neonates and infants showing low levels of retinol in the blood.
Setting:
Vanderbilt University School of Medicine.
Results:
Evidence is presented that vitamin A can be administered safely to human neonates and infants without apparent acute toxic effects.
Conclusion:
A carefully designed mode of administration of vitamin A can improve a patient's vitamin A status as determined by the elevation of blood vitamin A levels which in turn may be beneficial in lowering the morbidity.
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