Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Invasion and metastasis

D Boyd1

  • 1Department of Head and Neck Surgery/Tumor Biology, University of Texas, M.D. Anderson Cancer Center, USA.

Cancer Metastasis Reviews
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Understanding molecular mechanisms of head and neck squamous cell carcinoma (HNSCC) invasion is crucial. Research focuses on hydrolases like plasminogen activator and collagenases, aiming to reduce tumor spread and improve patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of bitewing radiography on estimates of dental caries experience among children differs according to their disease experience.

BMC oral health·2018
Same author

Alcohol misuse-a national pandemic: an investigation to identify whether implementing an alcohol brief intervention service would benefit patients attending an oral and maxillofacial (OMFS) department.

Public health·2017
Same author

Measuring acute postoperative pain using the visual analog scale: the minimal clinically important difference and patient acceptable symptom state.

British journal of anaesthesia·2017
Same author

A randomised controlled trial of peri-operative pregabalin vs. placebo for video-assisted thoracoscopic surgery.

Anaesthesia·2015
Same author

Cytology specimen adequacy using different papanicolaou smear techniques.

Journal of lower genital tract disease·2015
Same author

Temporal analysis of dissolution by-products and genotoxic potential of spherical zinc-silicate bioglass: "imageable beads" for transarterial embolization.

Journal of biomaterials applications·2014
Same journal

HER2 assessment in urothelial carcinoma: standardization challenges and the path forward.

Cancer metastasis reviews·2026
Same journal

Resolving translational challenges in cancer biology through yeast experimental evolution.

Cancer metastasis reviews·2026
Same journal

Spheroids and organoids to study long noncoding RNAs in cancer: how they could replace animal models.

Cancer metastasis reviews·2026
Same journal

Strategies and successes of smoking cessation methods in head and neck cancer patients: a systematic review.

Cancer metastasis reviews·2026
Same journal

The Hippo signaling pathway in pediatric brain tumors: molecular mechanisms and therapeutic opportunities.

Cancer metastasis reviews·2026
Same journal

Antibody-drug conjugates in breast cancer brain and leptomeningeal metastases: mechanistic insights and therapeutic progress.

Cancer metastasis reviews·2026
See all related articles

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Squamous cell carcinoma of the head and neck (HNSCC) poses significant clinical challenges due to its invasive nature.
  • Tumor resection often impairs vital functions (speech, swallowing) and necessitates costly reconstructive surgery.
  • Understanding the molecular basis of HNSCC local and regional spread is critical for improved patient care.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying the invasive spread of head and neck squamous cell carcinoma.
  • To identify key hydrolases involved in tumor invasion and their regulation.
  • To pave the way for novel therapeutic strategies targeting HNSCC invasiveness.

Main Methods:

  • Investigating the role of hydrolases, including urokinase-type plasminogen activator and collagenases (types I and IV), in HNSCC invasion.

Related Experiment Videos

  • Analyzing the transcriptional regulation and signal transduction pathways controlling hydrolase expression in tumor cells.
  • Identifying tumor-derived factors that induce hydrolase expression in surrounding stromal fibroblasts.

    • Main Results:

    • Several hydrolases, such as urokinase-type plasminogen activator, type I and IV collagenases, and stromelysins, are implicated in HNSCC spread.
    • Mechanisms of hydrolase overexpression involve transcriptional activation via signal transduction pathways in tumor cells.
    • Tumor-derived growth factors can induce hydrolase expression in stromal fibroblasts (e.g., stromelysin-2 and -3).

    Conclusions:

    • Targeting hydrolase activity and their regulatory pathways presents a promising therapeutic avenue for HNSCC.
    • Elucidating the molecular interactions between tumor cells and stromal fibroblasts is key to inhibiting invasion.
    • Reducing HNSCC invasiveness can lead to improved survival rates and quality of life for patients.