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The GENNID Study. A resource for mapping the genes that cause NIDDM
L J Raffel1, D C Robbins, J M Norris
1Cedars-Sinai Research Institute, Los Angeles, California 90048, USA. lraffel@mailgate.csmc.edu
Diabetes Care
|August 1, 1996
Summary
The Genetics of NIDDM (GENNID) project is creating a valuable resource of family data and cell lines to aid in identifying genes for non-insulin-dependent diabetes mellitus (NIDDM). This resource will accelerate genetic studies of NIDDM.
Area of Science:
- Genetics
- Endocrinology
- Public Health
Background:
- Non-insulin-dependent diabetes mellitus (NIDDM) has a significant genetic component that remains incompletely understood.
- Identifying NIDDM genes requires comprehensive genetic and phenotypic data from well-characterized families.
Purpose of the Study:
- To establish a publicly available resource of comprehensive data and lymphoblastoid cell lines from multiplex NIDDM families.
- To facilitate genetic studies aimed at identifying the genes responsible for NIDDM.
Main Methods:
- Collection of multiplex NIDDM families across diverse ethnic groups (Non-Hispanic white, Hispanic, African-American, Japanese-American).
- Detailed collection of family histories, medical histories, and phenotypic data, including glucose tolerance and insulin measurements.
- Establishment of lymphoblastoid cell lines for all family participants.
Main Results:
- The GENNID program has studied over 1,400 individuals from approximately 220 families since its inception in July 1993.
- The project aims to collect data from 300 non-Hispanic white, over 100 Hispanic, over 100 African-American, and 15 Japanese-American families by July 1997.
Conclusions:
- The identification of NIDDM genes is now potentially achievable with linked genetic and phenotypic data.
- The GENNID project provides a crucial resource to expedite the discovery of the genetic basis of NIDDM.