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Related Experiment Videos

Anorectal dysfunction in systemic sclerosis

K C Kim1, H J Park, S K Lee

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Journal of Korean Medical Science
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

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Systemic sclerosis (SSc) patients exhibit anorectal dysfunction, evidenced by reduced rectal distention tolerance. Anorectal manometry is valuable for detecting SSc-related anorectal impairment, even before symptoms appear.

Area of Science:

  • Gastroenterology
  • Rheumatology
  • Clinical Physiology

Background:

  • Systemic sclerosis (SSc) is a multisystem autoimmune disease.
  • Gastrointestinal dysmotility is a common complication of SSc.
  • Anorectal dysfunction may occur in SSc patients.

Purpose of the Study:

  • To evaluate anorectal dysfunction in patients with SSc.
  • To determine the clinical significance of anorectal manometry in SSc.
  • To explore correlations between anorectal and esophageal manometry findings in SSc.

Main Methods:

  • Anorectal manometry was performed on seven SSc patients and 11 controls.
  • Esophageal manometry was conducted on SSc patients.
  • Rectal balloon distention tolerance was assessed.

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Main Results:

  • SSc patients had significantly lower rectal sensory and urgency volumes (P < 0.05).
  • No significant differences in anal sphincter pressures or anal canal length were observed.
  • Abnormal rectoanal inhibitory reflex was noted in 43% of SSc patients.
  • SSc patients frequently showed abnormal esophageal manometry, including decreased LES pressure.

Conclusions:

  • Anorectal function may be impaired in SSc, suggesting potential anorectal involvement.
  • Anorectal manometry is a useful tool for detecting subclinical anorectal dysfunction in SSc.
  • No significant correlation was found between anorectal and esophageal manometric abnormalities in this SSc cohort.