[Changes in the processes of bone marrow cell proliferation and differentiation in white mice under the influence of...

In experiments carried out on albino mice daily heparin injections (250 units/kg) for two weeks resulted in 30% increase of leukocyte count in the venous blood. The femur bone marrow kariocyte count remained unchanged, while the leukoerythroblastic ratio rose from 4.1 to 7.6. Autoradiography demonstrated that the duration of the mitotic cycle and its phases in myeloid cells underwent no change, constituting: T--13 hrs, ts--8 hrs, tG2--1 hour, t(G1+M)--4 hrs. In heparinized animals the curve of labeled mitoses was nearly ideal. It is suggested that there occurred a change in the stem cells differentiation towards the myeloid type in the bone marrow under the effect of heparin.