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Related Experiment Videos

Hyperinsulinemia is associated with ventricular premature complexes

G Paolisso1, P Gualdiero, D Manzella

  • 1Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy.

Metabolism: Clinical and Experimental
|October 1, 1996
PubMed
Summary

High fasting plasma insulin (FPI) levels are linked to ventricular premature complexes (VPCs) in individuals without diabetes or heart disease. This association suggests insulin resistance may play a role in cardiac arrhythmias.

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Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Fasting plasma insulin (FPI) is a marker of insulin resistance.
  • Ventricular premature complexes (VPCs) are common cardiac arrhythmias.
  • The relationship between FPI and VPCs in individuals without traditional risk factors is not well understood.

Purpose of the Study:

  • To investigate the association between fasting plasma insulin (FPI) levels and ventricular premature complexes (VPCs).
  • To explore this association in a cohort free of coronary artery disease, diabetes, and hypertension.

Main Methods:

  • 186 subjects without CAD, diabetes, or hypertension underwent 24-hour ECG monitoring and oral glucose tolerance testing.
  • Fasting plasma insulin, lipids, triglycerides, and potassium were measured.

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  • Statistical analyses included correlation and multiple logistic regression.

    • Main Results:

    • Higher FPI tertiles were associated with older age, higher BMI, central obesity, and increased VPCs.
    • FPI concentration independently correlated with VPCs (r = .19, P < .01).
    • The association remained significant after adjusting for multiple factors, but was attenuated by fasting plasma free fatty acids or potassium.

    Conclusions:

    • Fasting plasma insulin concentrations are associated with ventricular premature complexes in subjects without diabetes, hypertension, or ischemic heart disease.
    • Insulin resistance may contribute to cardiac arrhythmias in seemingly healthy individuals.
    • Further research is needed to elucidate the mechanisms linking FPI, metabolic factors, and VPCs.