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A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic
S K Tsui1, P P Chan, C W Cheuk
1Department of Biochemistry, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Biochemistry and Molecular Biology International
|July 1, 1996
Abstract:
A full-length cDNA clone encoding a zinc finger protein was isolated and sequenced. This full-length clone consists of 728 bp and has a predicted open reading frame (ORF) encoding 208 amino acids. The ORF of this polypeptide codes for the human cysteine-rich protein 2 (HCRP2) and has an amino acid sequence that is 92.8% identical to its rat homolog (RCRP2). HCRP2 was mapped to chromosome 14q32, which is a hot spot of translocation in tumor development, by fluorescent in situ hybridization (FISH).