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Reference range data for assessing exposure to selected environmental toxicants

L L Needham1, D G Patterson, V W Burse

  • 1Division of Environmental Health Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3714, USA.

Toxicology and Industrial Health
|May 1, 1996
PubMed
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This study measured environmental toxicants in Great Lakes fish consumers. Results will compare internal doses to reference ranges to assess exposure status.

Area of Science:

  • Environmental Health
  • Toxicology
  • Public Health

Background:

  • Consumption of fish from the Great Lakes may lead to exposure to environmental toxicants.
  • Assessing exposure levels is crucial for understanding potential health risks.

Purpose of the Study:

  • To measure levels of specific environmental toxicants in individuals consuming fish from the Great Lakes.
  • To compare measured internal dose levels against established reference ranges.
  • To determine the exposure status of study participants.

Main Methods:

  • Analysis of blood and urine specimens from 32 participants (charter boat captains, anglers, spouses).
  • Measurement of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and pesticides in serum.

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  • Analysis of nonpersistent pesticides and elements in urine, and elements in blood.

    • Main Results:

    • Selected environmental toxicants were quantified in blood and urine samples.
    • Internal dose levels were determined for various compounds.
    • Reference range data were compiled for comparison.

    Conclusions:

    • The study provides data on toxicant exposure in Great Lakes fish consumers.
    • Comparison with reference ranges will help ascertain exposure status.
    • Findings will inform public health assessments regarding Great Lakes environmental contaminants.