Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Post-malaria neurological syndrome

T H Nguyen1, N P Day, V C Ly

  • 1Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Vietnam.

Lancet (London, England)
|October 5, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peer facilitators in interprofessional education: a promising response to facilitation challenges.

BMC medical education·2026
Same author

Natural history of relapsed myeloma, refractory to immunomodulatory drugs and proteasome inhibitors: a multicenter IMWG study.

Leukemia·2017
Same author

Determining the effect of vein visualization technology on donation success, vasovagal symptoms, anxiety and intention to re-donate in whole blood donors aged 18-30 years: A randomized controlled trial.

Vox sanguinis·2016
Same author

The Role of Cognitive Factors in Predicting Balance and Fall Risk in a Neuro-Rehabilitation Setting.

PloS one·2016
Same author

British Thoracic Society guidelines for the investigation and management of pulmonary nodules.

Thorax·2015
Same author

Compliance with the current 12-month deferral for male-to-male sex in Australia.

Vox sanguinis·2013

Post-malaria neurological syndrome (PMNS) is a rare but serious condition. Mefloquine use after severe malaria treatment increases PMNS risk, suggesting alternative drugs should be prioritized.

Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Neurology

Background:

  • Neurological complications are frequent in malaria.
  • A specific transient neurological syndrome has been observed post-malaria in Southeast Asia.

Purpose of the Study:

  • To prospectively investigate the incidence and characteristics of post-malaria neurological syndrome (PMNS).
  • To identify risk factors associated with PMNS development.

Main Methods:

  • Prospective study conducted over four years in Vietnam.
  • Inclusion criteria: recent malaria, parasite clearance, and new neurological/psychiatric symptoms within two months.
  • Half of severe malaria patients participated in an antimalarial drug trial.

Main Results:

Related Experiment Videos

  • 19 adults and 3 children developed PMNS out of 18,124 malaria patients.
  • Overall PMNS incidence was 1.2 per 1000; risk was 299 times higher after severe malaria.
  • PMNS symptoms included confusion, psychosis, and convulsions; the syndrome was self-limiting.
  • Mefloquine use was associated with increased PMNS risk (RR 9.2 vs. quinine).

Conclusions:

  • Mefloquine is a significant risk factor for PMNS.
  • Avoid mefloquine for severe malaria treatment when effective alternatives exist.