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Inorganic fluoride concentration after long-term sedation with isoflurane
M A Osborne1, J M Eddleston, W McNicoll
1Intensive Care Unit, Withington Hospital, Manchester, UK.
Intensive Care Medicine
|July 1, 1996
Summary
Long-term isoflurane sedation (up to 7 days) was successfully used in five patients. Daily monitoring showed serum inorganic fluoride levels remained below renal toxicity thresholds, indicating no adverse renal effects.
Area of Science:
- Anesthesiology
- Nephrology
- Pharmacology
Background:
- Long-term sedation is crucial for critically ill patients.
- Isoflurane is an inhaled anesthetic agent.
- Assessing the safety of prolonged isoflurane use is important.
Observation:
- Five patients received continuous isoflurane sedation for up to 7 days.
- Serum inorganic fluoride levels were monitored daily.
- Fluoride concentrations ranged from 12 to 29 mmol/L.
Findings:
- Isoflurane sedation was clinically successful in all five patients.
- Measured serum inorganic fluoride levels were consistently below the established renal toxic level of 50 mmol/L.
- No evidence of renal function deterioration was observed during or after isoflurane administration.
Implications:
- Prolonged isoflurane sedation appears safe regarding renal function.
- This study supports the use of isoflurane for extended sedation protocols.
- Further research could explore optimal dosing and monitoring for long-term isoflurane use.