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Amyloidosis localized in the sigmoid colon
1Department of Internal Medicine, Uwajima Social Insurance Hospital, Ehime, Japan.
Journal of Gastroenterology
|August 1, 1996
Summary
This study reports a rare case of localized sigmoid amyloidosis in a 79-year-old woman presenting with bloody stool. The condition, characterized by sigmoid colon ulcerations and amyloid deposition, is exceptionally uncommon.
Area of Science:
- Gastroenterology
- Pathology
- Rare Diseases
Background:
- Amyloidosis is a group of diseases characterized by the deposition of amyloid protein.
- Localized amyloidosis can affect various organs, including the gastrointestinal tract.
- Colonic amyloidosis is a rare manifestation, with limited reported cases.
Observation:
- A 79-year-old female presented with bloody stool.
- Colonoscopy revealed extensive, irregular ulcerations in the sigmoid colon.
- Histopathology confirmed amyloid material deposition in the mucosa and submucosa of the sigmoid colon.
Findings:
- Endoscopic examination excluded similar lesions in the esophagus, stomach, and duodenum.
- Biopsies from other gastrointestinal areas did not show amyloid deposition.
- Systemic diseases like myeloma or collagen disease were ruled out through further investigations.
- The case was diagnosed as localized sigmoid amyloidosis, the fifth reported in Japan over 15 years.
Implications:
- This case highlights the importance of considering localized sigmoid amyloidosis in patients with unexplained lower gastrointestinal bleeding.
- Accurate diagnosis requires thorough endoscopic and histopathological evaluation.
- Understanding the rarity and presentation of this condition aids in clinical management and research.