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Updated: Jul 22, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Amelanotic Spitzoid melanoma in the burn scar of a child
Z Ghorbani1, Y Dowlati, A H Mehregan
1Center for Research and Education in Skin Disease and Leprosy, Tehran, Iran.
Abstract:
We report a 3-year-old girl with a rapidly growing, amelanotic, nodular melanoma developing within a burn scar over the dorsal aspect of the left foot. Histologically, the lesion was spindle cell and exhibited lack of maturation, cellular atypia, and scattered mitotic figures. Twenty five percent of the tumor cells were positive for proliferating cell nuclear antigen by immunohistochemical stain. A left inguinal lymph node was also positive for regional metastasis. The child died with disseminated metastases 13 months after the lesion was removed.
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