Clinical impact of adrenal expansive lesions in bronchial carcinoma

To estimate the prevalence of adrenal expansive lesions in patients with bronchial carcinoma, and assess the relationships among adrenal masses, TNM classification, and histology of the bronchial carcinoma, and to reveal other signs of inoperability in these patients.

CT findings of the thorax and upper abdomen in 96 patients with bronchial carcinoma were reviewed. Brain- and upper abdominal metastases, together with TNM classification and histology of the bronchial carcinoma, was recorded. CT was performed with 10-mm slice thickness from the thorax aperture to the renal hilum under i.v. contrast medium injection.

Eight adrenal expansive lesions (1.5-10 cm, mean 4.6 cm) were revealed in 6 of the 96 patients (6.3%). Two of these patients, classified as N0, had metastases in other organs; one had brain metastases and the other liver metastases. The bronchial carcinomas in the remaining 4 patients were classified as N3. Three of the patients had adenocarcinoma, one each of small-cell-, large-cell-, and unclassified bronchial carcinoma. Squamous cell carcinoma was most common in the total patient population, but no patient with adrenal masses showed this histologic type.

The finding of adrenal expansive lesions in bronchial carcinoma has little clinical impact, because these patients usually show other signs of inoperability. Hence, the value of upper abdominal CT as a routine examination is questionable.