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Bullous pemphigoid induced by radiation therapy
G Folliero1, A Zurlo, C Amanti
1University of Rome La Sapienza, Italy.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|January 1, 1995
Summary
A rare skin condition, bullous pemphigoid, developed in a breast cancer patient after radiation therapy. This first-time report highlights a potential side effect of radiation treatment.
Area of Science:
- Oncology
- Dermatology
- Radiation Oncology
Background:
- Conservative surgery and radiation therapy are common breast cancer treatments.
- Radiation therapy can cause various systemic cutaneous side effects.
- Bullous pemphigoid is a rare autoimmune blistering skin disease.
Observation:
- A female patient developed a diffuse bullous pemphigoid eruption in the radiation-treated area three weeks post-radiotherapy.
- The eruption subsequently spread to the entire body.
- This represents the first reported case of bullous pemphigoid in a female patient following breast cancer radiation therapy.
Findings:
- Diagnosis of bullous pemphigoid was confirmed.
- Treatment with nicotinamide and tetracycline was initiated and found effective.
- The case underscores a rare but significant adverse event associated with radiation therapy for breast cancer.
Implications:
- Oncologists and physicians must be aware of this rare complication.
- Early recognition and diagnosis are crucial for effective management.
- This finding is important given the increasing adoption of conservative breast cancer management.