Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PGM1 subtypes in Cantabria (middle N Spain)

R Calvet1, I Sánchez-Molina, J M Pastor

  • 1Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain.

Gene Geography : a Computerized Bulletin on Human Gene Frequencies
|April 1, 1995
PubMed
Summary

Red cell Phosphoglucomutase (PGM1) allele frequencies in Spain were analyzed. Results show similarity to European populations, with a 30.24% exclusion rate for paternity testing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Traffic-related air pollution in utero modifies cytokine responses to stimuli of umbilical cord blood cells: a cohort study.

Environmental research·2026
Same author

Pedestrian collective motion in competitive room evacuation.

Scientific reports·2017
Same author

Inverse gas chromatography a tool to follow physicochemical modifications of pharmaceutical solids: Crystal habit and particles size surface effects.

International journal of pharmaceutics·2015
Same author

Removal of lead(II) from aqueous solution using modified palygorskite, contribution of inverse gas chromatography.

Journal of chromatography. A·2015
Same author

Formation of porous SnS nanoplate networks from solution and their application in hybrid solar cells.

Chemical communications (Cambridge, England)·2015
Same author

Flow and clogging of a sheep herd passing through a bottleneck.

Physical review. E, Statistical, nonlinear, and soft matter physics·2015

Area of Science:

  • Human genetics
  • Population genetics
  • Biochemistry

Background:

  • Phosphoglucomutase (PGM1) is a crucial enzyme in human red blood cells.
  • Understanding PGM1 allele frequencies is vital for population genetics and forensic applications.
  • Previous studies have established PGM1 allele distributions in various global populations.

Purpose of the Study:

  • To determine the allele frequencies of the red cell Phosphoglucomutase (PGM1) enzyme system in a Spanish population.
  • To compare these frequencies with those reported in other European and Spanish populations.
  • To calculate the theoretical exclusion rate for paternity testing based on PGM1 polymorphism.

Main Methods:

  • Isoelectric focusing in polyacrylamide gel electrophoresis was used to analyze PGM1 phenotypes.
  • A sample of 500 unrelated individuals from Cantabria, Spain, was studied.
  • Allele frequencies were calculated based on the observed phenotype distributions.

Main Results:

  • The observed allele frequencies for PGM1 were PGM1*1+: 0.643, PGM1*1-: 0.121, PGM1*2+: 0.195, and PGM1*2-: 0.041.
  • These frequencies are comparable to those previously reported for other European and Spanish populations.
  • A theoretical exclusion rate of 30.24% was calculated for disputed paternity cases.

Conclusions:

  • The PGM1 allele frequencies in the Cantabrian population are consistent with those found in broader European populations.
  • The PGM1 system provides a significant exclusion efficiency for paternity testing in this Spanish population.
  • This study contributes to the understanding of human genetic variation within Spain.

Related Experiment Videos