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Valproate in status epilepticus

L M Holle1, B E Gidal, D M Collins

  • 1Division of Pharmacy, MD Anderson Cancer Center, University of Texas, Houston 77030, USA.

The Annals of Pharmacotherapy
|October 1, 1995
PubMed
Summary
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Valproate offers a viable treatment for refractory status epilepticus when standard therapies fail. Rectal administration of valproate in adults and children provides an alternative route for managing this neurological emergency.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Status epilepticus (SE) is a neurological emergency characterized by prolonged seizures.
  • Intractable SE often requires escalating treatment strategies when initial therapies are ineffective.

Purpose of the Study:

  • To evaluate valproate as a therapeutic option for patients with intractable status epilepticus.
  • To describe the administration and dosing of extemporaneously prepared valproate formulations.

Main Methods:

  • Review of clinical data for patients with intractable status epilepticus treated with valproate.
  • Administration of valproate via rectal suppositories or retention enemas.
  • Concurrent administration of phenytoin, phenobarbital, or both.

Main Results:

Related Experiment Videos

  • Valproate was utilized in patients refractory to benzodiazepines, phenytoin, and barbiturates.
  • Adult dosages ranged from 200-1200 mg every 6 hours.
  • Pediatric dosages were 15-20 mg/kg.

Conclusions:

  • Valproate is a potential treatment for intractable status epilepticus.
  • Rectal administration of valproate provides an alternative route for seizure management.
  • Dosing strategies for both adult and pediatric populations were established.