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Updated: Aug 18, 2026
Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
Published on: January 12, 2018
Osmotic scan ektacytometry in clinical diagnosis
1Department of Biochemistry, Wayne State University Medical School, Detroit, MI 48201, USA.
Purpose:
The use of red blood cell deformability measurements in the diagnosis of hemolytic anemia is reviewed.
Patients And Methods:
Results from 500 individuals are discussed. Erythrocytes were characterized by the automated measurement of cell deformability as the tonicity of the medium is varied (osmotic scan ektacytometry).
Results:
The measurement yields a reliable identification of hemolytic anemias caused by deficiencies or abnormalities in erythrocyte structural proteins. In addition, it can, with good reliability, signal the presence of a glycolytic enzyme deficiency. The scan is complete in 15 min, and can therefore give a rapid indication of the type of hemolytic anemia. The osmotic scans of other hemolytic anemias are also discussed.
Conclusion:
The analysis of red blood cell deformability can offer a valuable addition to diagnostic methods in hemolytic anemia.
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