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Status of antimalarial drugs under development
1Steering Committee on Drugs for Malaria, UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland.
Bulletin of the World Health Organization
|January 1, 1995
Summary
New antimalarial drugs are nearing development for treating drug-resistant malaria. Ensuring affordable access to these vital treatments for affected populations is crucial.
Area of Science:
- Malariology
- Pharmacology
- Infectious Diseases
Background:
- Urgent need for novel antimalarial drugs against multiresistant *falciparum* malaria.
- Limited pipeline of antimalarial candidates in advanced development stages.
Purpose of the Study:
- To review current antimalarial drug development.
- To highlight promising candidates and the need for accessible pricing.
Main Methods:
- Review of preclinical and clinical development stages of antimalarial drugs.
- Identification of key drug classes and specific compounds.
Main Results:
- Several drug classes show promise, including artemisinin derivatives, pyronaridine, benflumetol, new antifolates, atovaquone, and a novel 8-aminoquinoline.
- These drugs exhibit improved efficacy and safety profiles compared to existing treatments.
Conclusions:
- New antimalarial drugs are expected in the coming years.
- Mechanisms for affordable global access are essential for populations most affected by malaria.