Some physiological outcomes of renin gene studies

1. The cloning of the renin gene has permitted studies of its physiological regulation, extrarenal expression and role in disease. 2. Marked modulation of renin mRNA concentration is seen in adrenal, heart and hypothalamus in response to sodium depletion and inhibition of AII formation, as well as in models of renal and genetic hypertension in the rat. 3. One important outcome of studies of the promoter has been the discovery of a cyclic AMP-responsive sequence. 4. Sequence variations have been detected in or near the renin gene and have been used as markers in studies of its role in cardiovascular disease aetiology. 5. In conclusion, molecular biology has, in the past decade, made a significant contribution to the understanding of renin physiology and pathophysiology.