Multiparameter case studies using knowledge-based systems in hematology
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Updated: Nov 4, 2026

Workflow for Automated Digital Peripheral Blood and Bone Marrow Cytomorphology, With Consideration of Critical Cellular Misclassifications
Published on: July 28, 2026
L W Diamond1, P B Tamino, A H Seal
1Pathology Institute, University of Cologne Medical School, Germany.
Abstract:
Knowledge-based systems in diagnostic medicine are often used for teaching medical decision making. We have extended the educational value of our suite of hematology decision support systems (peripheral blood analysis, flow cytometry immunophenotyping and DNA analysis, and bone marrow morphology) by creating case studies in a hypertext format. The case studies use the knowledge-based system screens as a background. Digitized images of blood and bone marrow smears from the teaching cases can be accessed on-line. The case studies, which are designed primarily for technologists and physicians, emphasize the proper multiparameter approach to hematopathology diagnosis.
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