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[Ischemic hepatitis]

L Gepstein1, Y Edoute

  • 1Dept. of Medicine C, Rambam Medical Center, Haifa.

Harefuah
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Ischemic hepatitis, marked by high aminotransferase levels, often follows cardiac or respiratory failure. Prompt recognition aids diagnosis and avoids unnecessary, risky tests.

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Area of Science:

  • Hepatology
  • Cardiology
  • Critical Care Medicine

Background:

  • Ischemic hepatitis is characterized by significant, temporary elevations in serum aminotransferase levels.
  • It typically occurs without other identifiable causes of liver necrosis.
  • The condition is often linked to preceding cardiac complications or acute respiratory failure.

Observation:

  • Presents two cases of ischemic hepatitis in elderly patients (80-year-old woman, 76-year-old man).
  • Etiologies included hypotension secondary to rapid atrial fibrillation, sepsis, and acute respiratory failure.
  • Highlighted variations in laboratory results and clinical presentations.

Findings:

  • The histological hallmark of ischemic hepatitis is centrilobular hepatic necrosis.

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  • Patients experienced transient, marked increases in serum aminotransferase activity.
  • The clinical course, as described in the literature and observed in these cases, is relatively benign.

    • Implications:

    • Emphasizes the importance of considering ischemic hepatitis in the differential diagnosis of acute hepatitis.
    • Awareness can prevent unnecessary and potentially harmful investigations.
    • Facilitates timely and appropriate patient management.