Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Somatostatin and large bowel polyps

J Payer1, M Huorka, I Duris

  • 11st Department of Internal Medicine, Comenius University, Bratislava, Slovak Republic.

Hepato-Gastroenterology
|November 1, 1995
PubMed
Summary

Somatostatin, a hormone, shows a circadian rhythm in patients with large bowel polyps. Altered somatostatin secretion patterns may indicate its role in preventing polyp and cancer development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myocardial fibrosis, the silent instigator of diastolic dysfunction in patients with rheumatoid arthritis.

Physiological research·2025
Same author

Parathyroid Hormone-Related Changes of Bone Structure.

Physiological research·2022
Same author

Fibroblast Growth Factor 23 and Klotho Are Associated With Trabecular Bone Score but Not Bone Mineral Density in the Early Stages of Chronic Kidney Disease: Results of the Cross-Sectional Study.

Physiological research·2022
Same author

Prediction of Vertebral Fractures by Trabecular Bone Score in Patients With Ankylosing Spondylitis.

Physiological research·2022
Same author

The Long-Term Effects of Growth Hormone Replacement on Bone Mineral Density and Trabecular Bone Score: Results of the 10-Year Prospective Follow-up.

Physiological research·2022
Same author

Ovarian Reserve Assessed by the Anti-Mullerian Hormone and Reproductive Health Parameters in Women With Crohn´s Disease, a Case-Control Study.

Physiological research·2022

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Chronobiology

Background:

  • Somatostatin is a polypeptide hormone that inhibits mucosal cellular proliferation.
  • Cellular proliferation is a characteristic of large bowel polyps and cancer.
  • Understanding somatostatin secretion patterns is crucial for disease comprehension.

Purpose of the Study:

  • To investigate the circadian rhythm of plasma somatostatin in patients with large bowel polyps.
  • To establish the pattern of somatostatin secretion in this patient group.

Main Methods:

  • Studied the 24-hour rhythmicity of plasma somatostatin.
  • Collected blood samples at regular intervals from patients with large bowel polyps.
  • Quantified plasma somatostatin levels using radioimmunoassay.

Related Experiment Videos

Main Results:

  • Confirmed a circadian rhythm of somatostatin in patients with large bowel polyps.
  • Observed a higher mesor (average level) in patients with polyps (p < 0.05).
  • Found a higher 24-hour amplitude and longer acrophase (peak time) in patients with polyps (p < 0.05).

Conclusions:

  • Findings suggest an antiproliferative defense role for somatostatin in premalignant and malignant conditions.
  • Somatostatin may offer therapeutic benefits for treating large bowel polyps.