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Updated: Aug 19, 2026

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
gamma-Glutamyl transpeptidase as a response predictor when using alpha-interferon to treat hepatitis C
D H Van Thiel1, L Friedlander, P Malloy
1Oklahoma Tansplant Institute, Baptist Medical Center of Oklahoma, Oklahoma City, USA.
Background/Aims:
This study was performed to identify response predictors for Interferon therapy given to patients with chronic hepatitis C.
Materials And Methods:
The biochemical measures of liver injury that characterize viral hepatitis due to hepatitis C were followed prospectively in 84 individuals treated with alpha-Interferon. In addition, the liver histology and the hepatic iron content of these same individuals, prior to the initiation of Interferon therapy, were determined.
Results:
Patients not responding to the interferon therapy showed an increase in liver iron content from an average of 337 micrograms/g wet weight. In responder to a value of 1075 micrograms/g wet weight in non responders. gamma-glutamyl transpeptidase levels in responders were significantly lower than in partial or non-responders.
Conclusions:
Both the hepatic iron content of the liver and the gamma-glutamyl transpeptidase value prior to treatment were able to predict a clinical response to Interferon therapy. More importantly, the gamma-glutamyl transpeptidase level measured in serum could be used to monitor the IFN response during treatment and was found to predict clinical exacerbations of hepatitis following withdrawal of Interferon therapy.
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