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Adaptation to eccentric exercise: effect on CD64 and CD11b/CD18 expression

F X Pizza1, B H Davis, S D Henrickson

  • 1Department of Physical Education, Texas Christian University, Forth Worth, 76129, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|January 1, 1996
PubMed
Summary
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Repeated eccentric exercise reduces circulating neutrophils and lowers neutrophil and monocyte activation, indicating an adaptation to exercise stress.

Area of Science:

  • Exercise Physiology
  • Immunology
  • Cell Biology

Background:

  • Eccentric exercise, characterized by muscle lengthening under tension, can induce muscle damage and inflammation.
  • Neutrophils and monocytes are key immune cells involved in the inflammatory response to exercise.

Purpose of the Study:

  • To investigate the impact of two bouts of eccentric exercise on circulating neutrophils and monocytes.
  • To assess the plasma membrane expression of CD64, CD11b, and CD18 on these immune cells as indicators of activation.

Main Methods:

  • Ten subjects performed two sessions of eccentric forearm flexor exercise separated by three weeks.
  • Blood samples were collected at multiple time points up to 96 hours post-exercise.
  • Immune cell activation markers (CD64, CD11b, CD18) were measured using direct immunofluorescence.

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Main Results:

  • Muscle damage markers (creatine kinase, myoglobin) and soreness were significantly lower after the second exercise bout (B2) compared to the first (B1).
  • Circulating neutrophils were elevated for longer periods after B1 versus B2.
  • Expression of CD11b, CD64, and CD18 on neutrophils and monocytes was generally higher after B1 compared to B2, particularly at later time points.

Conclusions:

  • Adaptation to eccentric exercise leads to a reduced inflammatory response.
  • This adaptation is characterized by fewer circulating neutrophils and a diminished activation state of neutrophils and monocytes.