Related Experiment Video
Updated: Aug 14, 2026

13:04
A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
A minimal and optimal cytotoxic T cell epitope within hepatitis C virus nucleoprotein
H Kita1, K Hiroishi, T Moriyama
1Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
The Journal of General Virology
|December 1, 1995
Abstract:
Amino acid residues 81-100 of the hepatitis C virus (HCV) nucleoprotein contain a cytotoxic T cell epitope that is recognized by cytotoxic T lymphocytes (CTLs) in association with human leukocyte antigen B44. With panels of truncated and overlapping peptides, the minimal and optimal epitope recognized by CTLs was shown to be a 9-mer peptide (residues 88-96). The peptide can stimulate effectively CTLs that are able to recognize endogenously synthesized and processed HCV nucleoprotein.

