Neuronal activities from a deep subcortical structure can be detected magnetically outside the brain in the porcine...

We assessed whether subcortical structures can generate magnetic fields detectable outside the brain by first measuring the somatic evoked magnetic fields (SEFs) from a decorticated porcine preparation and then from an intact preparation. Strong SEFs were detected a few millimeters above the corpus callosum after electrical stimulations of the snout. The waveforms consisted of a large spike ( < or = 6 pT) with a peak latency of 11-18 ms depending on the age of the animal, followed by a slow wave. The waveform and latency of the SEF spike were virtually identical to those of the field potential within the brain. The SEF topography indicated that the underlying generator of the spike was in a region contralateral to the stimulation and inferior to the thalamus. The subcortical SEF was strong enough to be detectable even above the intact brain, after the cortically generated SEF was removed by ablation of the primary cortical area. The results indicate that a structure deep in the brain can produce remarkably strong magnetic fields detectable outside the brain.