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Related Experiment Videos

Encoding, remembering and awareness in lorazepam-induced amnesia

H V Curran1, S Barrow, H Weingartner

  • 1Clinical Health Psychology, University College London, UK.

Psychopharmacology
|November 1, 1995
PubMed
Summary

Lorazepam impairs memory recall, particularly in implicit tasks like word-stem completion. These drug-induced deficits at encoding persist regardless of initial information processing levels.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Benzodiazepines like lorazepam are known to affect cognitive functions.
  • Understanding the impact of lorazepam on different memory processes is crucial.

Purpose of the Study:

  • To assess the effects of lorazepam on encoding, remembering, and awareness.
  • To investigate lorazepam's impact on explicit and implicit memory tasks.
  • To explore the role of levels of processing (L-o-p) in lorazepam-induced memory impairments.

Main Methods:

  • A double-blind study with 54 healthy volunteers.
  • Utilized a levels of processing (L-o-p) task for stimulus encoding.
  • Administered lorazepam (1.2 mg) or placebo.
  • Assessed memory using explicit (word recognition) and implicit (word-stem completion) tasks.

Related Experiment Videos

  • Investigated awareness of retrieval after the implicit task.

    • Main Results:

    • Lorazepam caused significant impairments in the implicit word-stem completion task.
    • Levels of processing (L-o-p) effects were observed in the implicit task.
    • Drug-induced deficits at encoding persisted regardless of L-o-p in explicit memory tasks.
    • Subjects were unaware of explicit retrieval during the implicit task.

    Conclusions:

    • Lorazepam impairs implicit memory, potentially due to contamination by explicit retrieval processes or effects on encoding.
    • Drug-induced memory deficits are independent of the initial level of information processing.
    • Lorazepam affects both encoding and retrieval processes in memory.