Physiological changes in antioxidant defences in fetal and neonatal rat liver

This study describes the physiological changes in the activities of the hepatic antioxidant enzymes superoxide dismutase isoenzymes (Cu/Zn-and Mn-superoxide dismutase) and catalase, in the glutathione content and in the lipid peroxidation levels in fetal (20 and 21 days of gestation) and neonatal rat liver (Days 1, 8, 15, and 22 post partum). The catalase and superoxide dismutase activities decreased before birth and increased after birth. The oxidized:reduced glutathione (GSSG:GSH) ratio declined before birth, but it increased between Days 1 and 15 post partum and then remained stable. Finally, newborn rat liver from the 1st day of life shows the highest susceptibility to lipid peroxidation. These results suggest that the changes in antioxidant defences could be related mainly to the beginning of diet intake after birth, which entails a higher hepatic metabolism rate, as well as a higher oxygen consumption.