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Decrypting class I MHC-bound peptides with peptide libraries
1Embryonic Science and Technology Department, Kyoto University, Japan.
Multiple peptides have been used as molecular tools to probe the selective, yet degenerative, recognition of peptides by class I major histocompatibility complex (MHC) molecules and T-cell receptors. The additive contributions from individual amino acids that have been identified experimentally can often be used to predict the binding of any peptide to class I MHC molecules, although other contributing factors will often result in this being an oversimplification.
Multiple peptides have been used as molecular tools to probe the selective, yet degenerative, recognition of peptides by class I major histocompatibility complex (MHC) molecules and T-cell receptors. The additive contributions from individual amino acids that have been identified experimentally can often be used to predict the binding of any peptide to class I MHC molecules, although other contributing factors will often result in this being an oversimplification.