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Percutaneous chronic epidural catheterization in the rabbit

H Taguchi¹, K Murao, K Nakamura

¹Department of Anesthesiology, Kansai Medical University Hospital, Osaka, Japan.

Acta Anaesthesiologica Scandinavica

|February 1, 1996

Summary

A novel percutaneous chronic epidural catheterization technique was established in rabbits. This minimally invasive method allows for the study of epidurally administered drugs in a small animal model.

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Area of Science:

Veterinary Anesthesiology
Surgical Techniques in Research Animals

Background:

Surgical epidural catheterization is established in small animals.
Percutaneous methods for chronic epidural catheterization in rabbits are not reported.

Purpose of the Study:

To establish a technique for percutaneous chronic epidural catheterization in rabbits.
To validate the use of this model for drug administration studies.

Main Methods:

A percutaneous lumbar epidural catheterization was performed in 15 rabbits under pentobarbital anesthesia.
A 19-gauge Tuohy needle and a 23-gauge Nylon catheter were used with a paramedian approach.
Subcutaneous tunneling was performed to exteriorize the catheter from the neck.

Main Results:

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The procedure was successful in all rabbits, with no significant adverse effects.
Epidural administration of lidocaine induced temporary hind-limb motor paralysis (15-25 min).
Autopsy confirmed correct catheter placement in the lumbar epidural space.

Conclusions:

A reliable percutaneous chronic epidural catheterization technique in rabbits was developed.
This model is suitable for investigating the effects of epidurally administered drugs in small animals.