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Effect of indapamide on left ventricular hypertrophy in hypertension: a meta-analysis
P A Carey1, D J Sheridan, A de Cordoue
1Academic Cardiology Unit, St. Mary's Hospital Medical School, Paddington, London, United Kingdom.
Insights
Diuretics like indapamide can reduce left ventricular hypertrophy, a key risk factor for heart disease. This meta-analysis shows 6 months of indapamide significantly decreased left ventricular mass, primarily by reducing wall thickness.
Area of Science:
- Cardiology
- Pharmacology
- Internal Medicine
Background:
- Left ventricular hypertrophy (LVH) is a significant risk factor for cardiovascular morbidity and mortality.
- While ACE inhibitors, calcium antagonists, and beta-blockers are known to prevent and regress LVH, the efficacy of diuretics remains less clear.
Purpose of the Study:
- To evaluate the effect of indapamide on left ventricular mass.
- To determine if diuretics can prevent or cause regression of left ventricular hypertrophy.
Main Methods:
- A meta-analysis of six studies involving 197 patients (aged 20-75 years).
- Patients received 2.5 mg of indapamide daily for 6 months.
- Left ventricular mass index was the primary outcome measure.
Main Results:
- A mean reduction of 13.3% in left ventricular mass index was observed.
- The reduction was mainly attributed to decreased left ventricular wall thickness, not internal diameter.
Conclusions:
- Six months of daily indapamide treatment effectively reduces left ventricular mass.
- Indapamide demonstrates potential in managing left ventricular hypertrophy, particularly through its effects on ventricular wall thickness.
Abstract:
Left ventricular hypertrophy is a major risk factor for cardiovascular morbidity and mortality. Angiotensin-converting enzyme inhibitors, calcium antagonists, and beta-blockers prevent, and cause regression of, left ventricular hypertrophy after short-term therapy. The ability of diuretics to do the same is unclear. We have performed a meta-analysis of studies documenting the effect on left ventricular mass of 6 months' treatment with 2.5 mg indapamide daily. Six studies comprising 197 patients, aged 20-75 years, were included. There was an overall mean reduction in left ventricular mass index of 13.3%, which was principally due to a reduction in left ventricular wall thickness rather than internal diameter.