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Updated: Sep 11, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Prematurity, low birth weight and the interval between pregnancies]
C Ochoa Sangrador1, C Luque Benlloch, A Carrascal Tejado
1Servicio de Pediatría, Hospital Virgen de la Concha, Zamora.
Background:
In the literature, it is not clear what influence a short interpregnancy interval has on the risk of prematurity and low birth weight.
Methods:
Between 5.241 births, we selected 279 pairs of newborns consecutive of the same mother, excluding multiple pregnancies and fetal loss. We investigated the relation of the interval between pregnancies to the risk of prematurity-low birth weight.
Results:
Our newborns with shorter interpregnancy intervals had a lower birth weight. Among the of less than 3 months the prevalence of prematurity-low birth weight was slightly greater (7.1%, OR: 2.14), although the difference didn't reach statistical signification. The multiple logistic-regression analysis determined that the only significantly predictive variable was the previous history of prematurity or low birth weight (OR = 12.49; C.I.95% 3.4-44.4).
Conclusions:
The short interpregnancy interval has had a scarce effect on the risk of prematurity and low birth weight. They are another obstetrical risk factors interrelated with greater impact to the gestational outcome.
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