Ultrasound tissue displacement imaging with application to breast cancer

A method for quantitative imaging of internal tissue motion based on speckle tracking is described. Tissue displacement images from eight patients with sonographically apparent breast masses are used to illustrate the technique. The local displacement response of tissues surrounding malignant and benign breast masses is compared, testing the hypothesis that altered mechanical properties may result in motion signatures for many soft tissue tumors relative to their host tissue. In addition, the potential or anticipated influence of various biological and physical factors on tissue motion response is discussed.