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Temperature variations in upright mechanical freezers

S C Su1, S Garbers, T D Rieper

  • 1Department of Environmental Medicine, New York University School of Medicine, New York 10010, USA.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|February 1, 1996
PubMed
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Upright freezers used for biological sample banking show significant temperature variability, with warmer zones in front and upper sections. This suggests they may not be ideal for long-term sample preservation in epidemiological studies.

Area of Science:

  • Biomedical science
  • Epidemiology
  • Laboratory science

Background:

  • Biological sample banks are crucial for large prospective cohort studies.
  • Maintaining stable, ultra-low temperatures is essential for long-term sample preservation.
  • Upright mechanical freezers are commonly used in research settings.

Purpose of the Study:

  • To assess temperature deviations within upright mechanical freezers.
  • To evaluate temperature variability between freezers.
  • To determine the impact of defrosting cycles on freezer temperature stability.

Main Methods:

  • Utilized an Omega Type T Thermocouple Microcomputer thermometer.
  • Monitored internal temperatures at 12 locations within 15 freezers set at -80°C.

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  • Analyzed temperature data, including deviations and variability.

    • Main Results:

    • Internal freezer temperatures ranged from -90°C to -43.5°C.
    • Significant temperature deviations were observed across different locations.
    • Warmer temperatures were consistently recorded in the upper and front sections of the freezers.

    Conclusions:

    • Upright front-loading mechanical freezers exhibit considerable temperature instability.
    • Temperature variations may compromise the integrity of biological samples.
    • These freezers might not be optimally suited for long-term epidemiological biobanking.