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Elevation of plasma interleukin-6 level in patients undergoing oral and maxillofacial surgery
T Miyawaki1, S Maeda, M Shimada
1Department of Dental Anesthesiology, Okayama University Dental Hospital, Japan.
Objective:
The purpose of this study was to evaluate the response of peripheral interleukin-6 associated with oral and maxillofacial surgery.
Study Design:
Fifteen patients undergoing elective oral and maxillofacial surgery were studied. We investigated the change in plasma interleukin-6 level during and after surgery and the correlation between plasma interleukin-6 level and surgical procedure. Plasma interleukin-6 levels were measured by enzyme-linked immunosorbent assay. Statistical significance was determined by nonparametric methods.
Results:
Elevation of plasma interleukin-6 level was detected at 2 to 6 hours after incision and observed to reach a peak level within 6 hours after the end of surgery. There were significant correlations between plasma interleukin-6 level and duration of surgery or response of C-reactive protein.
Conclusion:
The results suggested that interleukin-6 would be released by surgical injury and elevation of plasma interleukin-6 level would be associated with magnitude of tissue damage in oral and maxillofacial surgery.