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The radical scavenging abilities of a new anti-nephritic drug, OPC-15161
1Department of Bioregulation Research, National Institute of Radiological Sciences, Chiba, Japan.
Biochemistry and Molecular Biology International
|February 1, 1996
Abstract:
A new anti-nephritic drug, 6-(1H-indol-3-ylmethyl)-5-methoxy-3-(2-methylpropyl)-2-(1H)-pyr azi none 4-oxide (OPC-15161), a natural product derivative, did not react with the free radical, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and was only slightly reactive with superoxide (O2-), but it easily reacted with hydroxyl radical (.OH). The scavenging ability of OPC-15161 against .OH was dependent on its concentration, and formed a new radical species by reaction with .OH. The structure of this new radical species is proposed.