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Related Experiment Videos

Subcutaneously tethered temporary filter: pathologic effects in swine

B S Kuszyk1, A C Venbrux, M A Samphilipo

  • 1Department of Cardiovascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.

Journal of Vascular and Interventional Radiology : JVIR
|November 1, 1995
PubMed
Summary
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The Tempo-filter, a temporary caval filter, can be safely placed and removed up to six weeks later in swine. Mild vessel wall damage was observed, but placement and removal proved feasible.

Area of Science:

  • Vascular surgery
  • Medical device evaluation
  • Animal studies

Background:

  • Temporary caval filters are used to prevent pulmonary embolism.
  • The Tempo-filter is a temporary caval filter requiring evaluation for safety and efficacy.
  • Swine models are utilized for preclinical assessment of medical devices.

Purpose of the Study:

  • To assess the histopathologic effects of the Tempo-filter on the caval wall.
  • To determine the feasibility of deploying and removing the Tempo-filter in a swine model.

Main Methods:

  • Tempo-filters were implanted in the infrarenal inferior vena cava of 11 swine.
  • Different tethering catheters were evaluated for device migration and complications.
  • Vena cavography, in situ dissection, and filter removal were performed at various time points.

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Main Results:

  • Successful filter placement and removal (up to 6 weeks) were achieved in all animals.
  • Significant cephalic filter migration (>1 cm) occurred in most swine.
  • Stiffer tethering catheters were associated with increased complications, including caval stenosis, thrombus formation, pulmonary embolism, and mortality.

Conclusions:

  • The Tempo-filter can be feasibly placed and removed up to six weeks post-implantation.
  • Mild histopathologic changes were noted in the caval wall.
  • Further refinement of the tethering system may be necessary to mitigate migration and associated complications.