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[HIV-1 associated autonomic dysfunction (HIVAD)]

R Malessa1, P Ohrmann, M W Agelink

  • 1Neurologische Universitätsklinik, Essen.

Der Nervenarzt
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

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HIV-1 associated autonomic dysfunction (HIVAD) is common, affecting even asymptomatic patients. Peripheral autonomic surface potentials and autonomic testing reveal widespread nervous system impairment in HIV-1 infection.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Autonomic Neuroscience

Context:

  • HIV-1 infection frequently impacts multiple organ systems.
  • Autonomic nervous system (ANS) dysfunction is a recognized complication in HIV-1.
  • Understanding the prevalence and characteristics of HIV-1 associated autonomic dysfunction (HIVAD) is crucial for patient management.

Purpose:

  • To evaluate the prevalence and characteristics of HIV-1 associated autonomic dysfunction (HIVAD) in HIV-seropositive patients.
  • To utilize peripheral autonomic surface potentials (PASP) and a comprehensive autonomic test battery to assess ANS function.
  • To investigate the relationship between HIVAD and neurophysiological parameters in HIV-1 infection.

Summary:

  • Peripheral autonomic surface potentials (PASP) showed increased onset latencies and decreased amplitudes in HIV-1 patients, even those asymptomatic.

Related Experiment Videos

  • Autonomic testing revealed mild or marked HIVAD in 21% of patients each, affecting heart rate and blood pressure responses.
  • HIVAD was not correlated with sural and tibial nerve conduction changes, suggesting direct viral impact on the ANS.

    • Impact:

    • HIVAD is a frequent complication of HIV-1 infection, indicating a direct role of HIV-1 in its pathogenesis.
    • Both sympathetic and parasympathetic divisions of the ANS appear to be affected similarly in HIV-1 infection.
    • These findings highlight the need for routine autonomic function assessment in HIV-1 management.