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Selectin synthesis and inflammation
1Glaxo Institute for Molecular Biology, Geneva, Switzerland.
Trends in Biochemical Sciences
|February 1, 1996
Abstract:
The selectins are a family of three cell-surface-presented glycoprotein receptors. They play a key role in the initial adhesive interaction between leukocytes and endothelial cells at sites of inflammation. The presence of selectins on the cell surface is tightly regulated and inappropriate appearance is associated with a number of inflammatory disease conditions.