Related Experiment Video
Updated: Feb 8, 2026
08:01
Spectral and Angle-Resolved Magneto-Optical Characterization of Photonic Nanostructures
Published on: November 21, 2019
7.7K
Spectral characterization of fluconazole
T D Cyr1, B A Dawson, G A Neville
1Bureau of Drug Research, Health Canada, Ottawa, Ont.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1996
Summary
This study provides comprehensive spectral data for the antifungal drug fluconazole. These detailed spectroscopic analyses, including NMR and mass spectrometry, confirm its chemical structure.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Medicinal Chemistry
Background:
- Fluconazole is a potent antifungal agent.
- Comprehensive spectroscopic characterization is crucial for drug validation.
- Existing literature may lack detailed spectral data for fluconazole.
Purpose of the Study:
- To provide reference spectroscopic data (NMR, mass, IR, Raman) for fluconazole.
- To thoroughly analyze and assign spectral features.
- To validate the chemical structure of fluconazole through spectroscopic evidence.
Main Methods:
- Proton (1H), Fluorine-19 (19F), and Carbon-13 (13C) Nuclear Magnetic Resonance (NMR) spectroscopy.
- Electron Ionization (EI) Mass Spectrometry (MS), Fast Atom Bombardment (FAB) MS, and MS/MS.
- Infrared (IR) and Raman spectroscopy.
Main Results:
- Detailed assignments of 1H, 19F, and 13C NMR shifts and coupling constants.
- Mass spectrometry experiments (FAB, MS/MS) validated EI-MS data in the absence of a molecular ion.
- IR and Raman spectra provided complementary vibrational information, consistent with the fluconazole structure.
Conclusions:
- The study presents the first open literature reference spectra for fluconazole.
- The combined spectroscopic data definitively confirm the chemical structure of fluconazole.
- This data serves as a valuable resource for quality control and further research on fluconazole.
Related Concept Videos
02:39Emission Spectra
76.4K
When solids, liquids, or condensed gases are heated sufficiently, they radiate some of the excess energy as light. Photons produced in this manner have a range of energies, and thereby produce a continuous spectrum in which an unbroken series of wavelengths is present.
76.4K
01:25What is Population Genetics?
64.8K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.8K
01:57Meiosis II
208.8K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
208.8K
02:30Histone Variants at the Centromere
5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
02:13The Representativeness Heuristic
16.8K
The representative heuristic describes a biased way of thinking, in which you unintentionally stereotype someone or something. For example, you may assume that your professors spend their free time reading books and engaging in intellectual conversation, because the idea of them spending their time playing volleyball or visiting an amusement park does not fit in with your stereotypes of professors.
16.8K
02:12The Wave Nature of Light
61.5K
The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms and was able to demonstrate that white light consists of the individual colors of the rainbow combined together. Newton explained his optics findings in terms of a "corpuscular" view of light, in which light was composed of streams of extremely tiny particles traveling at high speeds according to Newton's laws of motion.
61.5K