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[Prolactinemia in children anesthetized with propofol]
M D del Campo-Martín1, A Garrido-Chercoles, L Pascual
1Servicio de Anestesiología y Reanimación, Hospital Nuestra Señora de Aránzazu, San Sebastián.
Revista Espanola De Anestesiologia Y Reanimacion
|January 1, 1996
Summary
Plasma prolactin levels significantly increased in children after anesthesia, regardless of spontaneous movements or anesthetic technique. These hormonal changes are attributed to the anesthetic induction dose, not patient movement or maintenance method.
Area of Science:
- Pediatric Anesthesiology
- Endocrinology
- Surgical Patient Care
Background:
- Propofol is a common anesthetic agent for pediatric procedures.
- Spontaneous movements during anesthesia can indicate inadequate pain control or anesthetic depth.
- Prolactin, a hormone, can be influenced by anesthetic agents and surgical stress.
Purpose of the Study:
- To investigate the relationship between plasma prolactin levels and spontaneous movements in children under propofol anesthesia.
- To compare the endocrine response of prolactin between two different anesthetic maintenance techniques.
Main Methods:
- Prospective study of 35 pediatric patients (4-11 years) undergoing minor surgery.
- Anesthesia induced with propofol; maintenance with either propofol infusion or isoflurane.
- Plasma prolactin levels measured pre-induction and post-extubation.
- Spontaneous movements assessed during induction to gauge pain response.
Main Results:
- A significant increase in postoperative prolactin levels was observed in all children, irrespective of spontaneous movements.
- No significant difference in prolactin levels was found between the propofol and isoflurane maintenance groups.
- Spontaneous movements were not correlated with elevated prolactin levels post-anesthesia.
Conclusions:
- Increased prolactin levels post-anesthesia in children are likely due to the propofol induction dose, not spontaneous movements.
- Anesthetic maintenance technique (propofol vs. isoflurane) did not significantly impact prolactin plasma levels.