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Effects of coronary artery diseases on haemorheological parameters and trace elements
U B Barutçu1, M C Akyolcu, A R Kiziler
1Department of Biophysics, Cerrahpaşa Medical Faculty, Istanbul, Turkey.
Insights
Coronary artery disease impacts blood viscosity, red blood cell flexibility, and hemoglobin levels. Bypass surgery may alter these haemorheological parameters and serum copper and zinc levels.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Hematology
Background:
- Coronary artery disease (CAD) is a significant health concern.
- Haemorheological parameters and trace elements play crucial roles in cardiovascular health.
- Understanding their changes post-surgery is vital for patient recovery.
Purpose of the Study:
- To investigate the effects of CAD on haemorheological parameters.
- To assess changes in serum trace elements (Cu, Zn) in CAD patients.
- To evaluate the impact of bypass surgery on these factors.
Main Methods:
- Studied 16 male patients with coronary artery disease.
- Collected blood samples pre-operation and at 10 and 30 days post-operation.
- Measured erythrocyte deformability (centrifugal method), blood viscosity (viscometer), hemoglobin (spectrophotometry), and trace elements (atomic absorption spectrophotometry).
Main Results:
- Coronary artery disease patients exhibited altered haemorheological parameters compared to normal values.
- Serum copper and zinc levels were investigated in relation to CAD and surgery.
- Post-bypass surgery, changes in blood viscosity, erythrocyte deformability, and trace element levels were observed.
Conclusions:
- Coronary artery disease significantly affects haemorheological parameters and serum trace element levels.
- Bypass surgery influences these physiological markers.
- Further research is warranted to elucidate the clinical implications of these findings.
Abstract:
The effects of coronary artery diseases on haemorheological parameters (blood viscosity, erythrocyte deformability and haemoglobin level) and serum trace element (Cu,Zn) levels were investigated. Subjects were 16 male patients having coronary artery disease. Three blood samples were drawn pre-operation and at the 10th and 30th day after operation. To determine the effects of by-pass surgery on haemorheological parameters and serum trace elements, we used a centrifugal method for erythrocyte deformability, Harkness relative viscometer for blood viscosity, spectrophotometry for haemoglobin level, and atomic absorption spectrophotometry for trace elements. Parameters of coronary artery patients were compared with normal values.