Related Experiment Videos
Evidence for a tachykinin/cholinergic mediation of D1 agonist-induced turning in mice
M Poncelet1, J Souilhac, G Le Fur
1Sanofi Recherche, Montpellier, France.
Abstract:
The turning behavior induced by the intrastriatal injection of the D1 agonist (+)SKF 38393 was blocked by the two selective nonpeptide tachykinin NK1 (SR 140333) (ID50 = 0.09 mg/kg ip) and NK2 (SR 48968) (ID50 = 1.4 mg/kg ip) receptor antagonists and by atropine (ID50 = 2.6 mg/kg ip). In addition, the turning induced by the intrastriatal injection of NK1 (septide) and NK2 ([Nle10]NKA(4-10)) receptor agonists were antagonized by atropine (ID50s = 1.1 mg/kg ip and 0.78 mg/kg ip, respectively). This behavioral study shows that tachykinin receptor activation is an essential component of DA-D1/Ach interaction in the mouse striatum and confirms the previously suggested functional importance of NK2 receptors in the central nervous system.