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Active and passive determinants of capillary density: a historical perspective
1Department of Physiology, University of Arizona, Tucson, USA.
International Journal of Microcirculation, Clinical and Experimental
|September 1, 1995
Summary
Capillary density, crucial for understanding blood flow, has been debated regarding its control mechanisms. Current research explores how endothelial shape changes may influence capillary network distribution.
Area of Science:
- Physiology
- Microcirculation Research
Background:
- Capillary density is a historically significant factor in understanding circulatory physiology.
- Its determination provided evidence for blood flow through tissue capillaries back to the heart.
Observation:
- Early theories proposed capillary contractility as a mechanism for controlling capillary density.
- Later research suggested arteriolar tone or passive mechanical factors were responsible for changes in capillary density.
Findings:
- While the prevailing view attributes capillary density changes to arteriolar tone or passive factors, active endothelial shape changes are under consideration.
- These endothelial shape changes could potentially alter blood flow distribution within the capillary network.
Implications:
- Understanding the control of capillary density is fundamental to comprehending microcirculation function.
- Further research into the active role of endothelial cells could refine our understanding of blood flow regulation.