Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitric oxide and bone

D M Evans1, S H Ralston

  • 1Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal plasma cortisol's effect on offspring birth weight: a Mendelian Randomisation study.

BMC pregnancy and childbirth·2024
Same author

The Effect of Anti-rheumatic Drugs on the Skeleton.

Calcified tissue international·2022
Same author

Risk of severe COVID-19 in patients with inflammatory rheumatic diseases treated with immunosuppressive therapy in Scotland.

Scandinavian journal of rheumatology·2022
Same author

Diagnosis and Management of Osteoporosis During COVID-19: Systematic Review and Practical Guidance.

Calcified tissue international·2021
Same author

Rheumatology in a time of Coronavirus: lessons from our early experiences.

QJM : monthly journal of the Association of Physicians·2020
Same author

Ferroelasticity, anelasticity and magnetoelastic relaxation in Co-doped iron pnictide: Ba(Fe<sub>0.957</sub>Co<sub>0.043</sub>)<sub>2</sub>As<sub>2</sub>.

Journal of physics. Condensed matter : an Institute of Physics journal·2019
Same journal

From loci to cells: mapping variant function in bone and joint diseases.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

The Journal of Bone and Mineral Research (JBMR) 40th anniversary celebration: the fourth decade (Part 2).

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Increased Prevalence of Coronary Artery Calcification in Patients with Post-Surgical Hypoparathyroidism.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Alendronate for 6 or 12 months following denosumab discontinuation in women with postmenopausal osteoporosis: A prospective observational study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

Is Zoledronic acid cost-saving in daily practice?

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same journal

MULTIDIMENSIONAL SPATIAL MAPPING OF EXTRACELLULAR MATRIX: CARTILAGINOUS-OSSEOUS COMPOSITE FORMATION, TENDON INTEGRATION AND VASCULARIZATION DURING SKELETAL GROWTH AND REPAIR.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
See all related articles

Nitric oxide (NO) regulates bone cells, suppressing osteoclasts at high levels but promoting osteoblasts at low levels. This dual role suggests NO

Area of Science:

  • Bone biology and molecular signaling
  • Immunology and inflammation
  • Biochemistry of nitric oxide

Background:

  • Nitric oxide (NO) is a key regulator of cardiovascular, neurotransmission, and immune functions.
  • Bone-derived cells express both constitutive and inducible forms of NO synthase.
  • Pro-inflammatory cytokines like IL-1, TNF, and IFN-gamma stimulate NO production in bone.

Purpose of the Study:

  • To investigate the multifaceted roles of nitric oxide (NO) in bone metabolism.
  • To elucidate the effects of NO on osteoblast and osteoclast lineage cells.
  • To explore the potential involvement of NO in bone diseases associated with cytokine activation.

Main Methods:

  • Analysis of NO synthase expression in bone cells.
  • Assessment of cytokine-induced NO production.

Related Experiment Videos

  • Evaluation of NO's impact on osteoclast formation and activity.
  • Investigation of NO's effects on osteoblast proliferation and function.

    • Main Results:

    • Interferon gamma (IFN-gamma) "superinduces" NO production, inhibiting osteoclast formation and activity.
    • High NO concentrations suppress osteoblast lineage cells and proliferation.
    • Moderate NO induction potentiates bone resorption.
    • Low concentrations of NO promote osteoblast proliferation and modulate function.

    Conclusions:

    • Nitric oxide (NO) acts as a critical regulatory molecule in bone, influencing both osteoblast and osteoclast lineages.
    • NO produced by osteoblasts directly modulates osteoclastic activity.
    • NO's involvement in cytokine-mediated bone diseases like rheumatoid arthritis and osteoporosis is suggested.