Related Experiment Video
Updated: Aug 6, 2026
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Case reports: delayed hemolytic transfusion reaction in sickle cell disease
S K Syed1, D A Sears, J B Werch
1Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Patients with sickle cell disease face high risks of delayed hemolytic transfusion reactions due to frequent transfusions and alloantibody formation. Enhanced phenotyping and matching of transfused cells are crucial preventive measures.
Area of Science:
- Hematology
- Transfusion Medicine
Background:
- Sickle cell disease patients require frequent transfusions, increasing exposure to foreign antigens.
- Alloimmunization is common due to antigenic differences between patients and donors.
Observation:
- Four cases of delayed hemolytic transfusion reactions in sickle cell disease patients are detailed.
- Exchange transfusions, used in three cases, heighten risks via increased antigen exposure.
Findings:
- Delayed hemolytic transfusion reactions present unique challenges in sickle cell disease management.
- Risk factors include prolonged transfusion history, alloantibody formation, and lack of transfusion records.
Implications:
- Extended erythrocyte phenotyping of patients is recommended.
- Extended phenotypic matching of transfused cells can mitigate transfusion reaction hazards.
More Related Videos
11:59Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
08:23Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
Related Concept Videos
02:45Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:27Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
01:19Rh Blood Group
01:15Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...